Kryptopyrroles Test

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The kryptopyrroles test indicates the level of what is more simply called ‘mauve factor’ in your urine.  It is the result of abnormal production of haemoglobin, of which the by-products are pyrroles, that then bind to vitamin B6 and zinc, causing large amounts of these nutrients to be excreted from the body.  As a result, deficiencies occur, enzyme reactions cannot take place efficiently and pyrrole disorder is commonly linked to a wide range of symptoms, primarily mental health disorders (including anxiety, but also schizophrenia or bipolar disorder) and also elevated histamine.

Deficiency of vitamin B6 can lead to the development of depression, nausea, fatigue and mental confusion, while zinc deficiency can cause poor immune function, acne and skin rashes, poor appetite, low stomach acid and attention or motor disorders.  Low zinc, B6 and magnesium deplete production of the neurotransmitters GABA and serotonin, which promote a sense of calm in the body, hence anxiety is one of the most common symptoms.

How to complete the Kryptopyrroles Test

Please read the test kit instruction booklet carefully, taking note to wash your hands before completing the test; not to discard the powdered preservative in the tall, dark coloured collection tube; to label both the tall dark tube and the thin monovette tube with yellow cap before completing the samples; and for women not to submit samples if you are menstruating.

4 days prior to testing. Stop taking any supplements, including protein powders (if you are taking zinc, vitamin B6, magnesium, manganese or evening primrose oil and can avoid them for a week, this would be ideal). There are no dietary restrictions to be aware of.

This is a time and light-sensitive sample and the test needs to be completed on a Sunday, in the dark, so will be best done late in the evening.  It requires you to be well hydrated, so if you are completing other tests which require fluid restriction, it would be best to complete them on different days.

Collect a mid-stream urine sample in the short, wide pot with yellow lid and then pour some urine into the tall dark-coloured collection tube, filling it two thirds full.  Replace the lid and immediately wrap the tube in the piece of tin foil provided.  Place the tube in the freezer, along with the ice pack and freeze them both overnight.  Return to the bathroom to complete the next sample, following instructions on how to use the monovette tube to draw up 10ml of the remaining urine from the short, wide pot.  The monovette collection tube does not need protection from the light, but also needs to be labelled and kept in the freezer overnight.

The samples should be couriered on a Monday to ensure no issues with sample spoilage.  You will need to phone your local branch of NZ Couriers to arrange for a pickup (you cannot call the 0800 number from a mobile phone, only a landline, but details of your local branch are on their website). Please also note that Post Shops will not accept NZ Couriers packages, so this needs to be collected from your home or work address, or dropped at an NZ Couriers depot.

Complete the patient questionnaire, fill in your details on the test request form, adding in details for Amanda Nutrition if not already done.  Ensure that you enclose both forms along with your samples – place both frozen collection tubes inside the padded white envelope, along with the ice pack, before placing into the courier bag.