Amanda has access to a wide range of genetic and pathology tests from private laboratories, which are valuable tools for assessing health and tailoring very personalised nutrition programmes. Please click on the links below, or scroll down for details of some of most commonly used tests, which include:
FitGenes Health & Wellbeing Genetic Profile Report
Personalised genetic profiling offers profound insight into how your body responds to diet, exercise and lifestyle choices. A FitGenes Health & Wellbeing Genetic Profile Report is based on the science of nutrigenomics, which looks at the interaction between your genes, nutrition and lifestyle and how these influence the genes’ messages. While we cannot change our genes, we can modify the way that they express themselves i.e. how they switch on and off and communicate with all cells of our body, to determine our health.
By linking our individual genetic signature with our family’s health history, our personal health history and current pathology testing (e.g. blood cholesterol, blood pressure, markers of inflammation, vitamin D), we can identify an individual’s predisposition towards certain health risks and make early interventions with regard to nutrition, lifestyle and exercise, before clinical symptoms start to appear.
The FitGenes genetic profile analyses a select range of genes that are key influencers of your general health, wellbeing and physical performance. They have been carefully selected on the basis of solid supporting scientific evidence, which demonstrates ways that we can modify their expression. As an accredited FitGenes practitioner, Amanda is able to interpret the results in conjunction with your personal health history and to offer practical advice on how to address any potential health issues, or to promote healthy ageing. A genetic profile is an invaluable tool in improving the gap between life expectancy and healthy expectancy i.e. rather than just living longer, aiming to extend your enjoyment of good health well into your later years of life.
The genes analysed are divided into the following categories:
Cell Defence – how your body protects cells and DNA from damage caused by oxidative stress
Inflammation – your body’s natural defence mechanism, which if uncontrolled, can be a key driver of almost all major diseases
Vitamin D receptors – present in all cells, these are a key influence on bone health, immunity, skin and the nervous system
Methylation and Homocysteine Metabolism – reflects the health of our cells and risk of chronic disease
Cardiovascular Health – the effectiveness of the system delivering oxygen and nutrients to every cell
Fat and Cholesterol Management – influence healthy weight management, appetite control and satiety
Test details: the test costs $650 and requires a simple DNA sample taken from a mouth swab. You will receive a copy of your genetic profile with supporting information and Amanda will help you to interpret the results, to create a highly personalised health plan.
Do you have a 23andMe profile but don’t know what to make of the results? The data from your profile can be imported into the FitGenes software to provide an in-depth analysis of the genetic variations that influence the way your body responds to what you eat, how you exercise and the way you live. Amanda can then interpret the results to create a personalised health programme.
Test details: the conversion costs $430.
FitGenes has developed Carb Choice, a personalised genetic profile report based on your AMY 1 gene, which determines how well you break down and tolerate starch from carbohydrates. This has a knock-on effect on many areas of health, so by understanding your Carb Choice gene profile, you can best manage health issues including:
Using your Carb Choice genetic profile, Amanda can design a personalised intervention plan, including recommendations on the type and quantity of carbohydrates that you are best suited to consume.
Test details: the test costs $299 and requires a simple DNA sample taken from a mouth swab. You will receive a report containing your AMY 1 gene copy number variation and further supporting information, with dietary and lifestyle recommendations.
Pathology Testing (prices vary according to different markers requested)
Comprehensive Digestive Stool Analysis with Parasitology
This test provides an excellent assessment of digestive function and is the appropriate choice for patients presenting with sub-optimal gut function. It measures:
digestive, absorption and metabolic markers
markers of inflammation, tumours or ulcers
levels of beneficial bacteria and potentially harmful bacteria such as streptococcus
levels of yeast, including candida
parasites and details of which pharmaceutical and natural products might be most effective in addressing each specific organism
Dried Urine Test for Comprehensive Hormones (DUTCH)
An advanced hormone test, using cutting edge technology to provide an extensive profile of sex and adrenal hormones, along with their metabolites i.e. showing not only what your hormone levels are, but also how your body is breaking them down and excreting them, which is often of greater significance. The comprehensive test includes:
daily free cortisol and cortisone
cortisol metabolites and DHEAS
8-OHdG, a marker for DNA damage
ALCAT Food Intolerance Test
There are many ways to test sensitivity to foods, but this blood test is a comprehensive and accurate way of measuring the reaction within your cells to over 450 substances, including foods, additives, environmental chemicals, inhalants and moulds. The results from the ALCAT test can help to determine which foods and other substances may trigger unwanted inflammation and associated gastrointestinal, metabolic or neurological disorders.
Organic Acids Test
The Organic Acids Test (OAT) offers a comprehensive metabolic snapshot of a patient’s overall health with over 70 markers. It provides an accurate evaluation of intestinal yeast and bacteria. Abnormally high levels of these microorganisms can cause or worsen behaviour disorders, hyperactivity, movement disorders, fatigue and immune function. Many people with chronic illnesses and neurological disorders often excrete several abnormal organic acids in their urine. The cause of these high levels could include oral antibiotic use, high sugar diets, immune deficiencies, acquired infections, as well as genetic factors. The test also includes markers for vitamin and mineral levels, oxidative stress, neurotransmitter levels, and is the only OAT to include markers for oxalates, which are highly correlated with many chronic illnesses.
Comprehensive Thyroid Profile
Hypothyroidism (underactive thyroid) is one of the most undiagnosed or misdiagnosed health problems. TSH (thyroid stimulating hormone) is the medical gold standard for the diagnosis and treatment of thyroid dysfunction. Unfortunately, TSH alone does not provide a complete picture and controversy remains over what is used as a ‘normal’ TSH reference range. Hashimoto’s thyroiditis is an auto-immune disease where the body attacks and destroys its own thyroid gland. It is a leading cause of hypothyroidism, yet mainstream thyroid tests rarely check thyroid antibodies.
A comprehensive thyroid profile, based on a blood sample shows:
Unbound levels of T4 and T3 – these reflect the active components of thyroid hormone. This hormone assessment can identify not only overt hyper-and hypothyroidism, but subtle sub-clinical manifestations of thyroid dysfunction.
Reverse T3 – levels of which can increase when conversion of T4 to active T3 is impaired. Thyroid imbalances may arise from nutrient shortages, heavy metal exposure, adrenal stress, enzyme deficiencies, and other chronic illness.
Thyroid antibody levels – which help gauge autoimmune response and may reflect metabolic irregularities and hypothyroidism even when TSH and T4 levels appear normal. Thyroid antibody levels may rise in response to trauma, bacterial imbalance, inflammation, or progressive thyroid degeneration.
The methylation cycle is a biochemical pathway that manages or contributes to a wide range of biochemical functions including detoxification, supporting DNA (turning genes on and off), producing energy, reducing inflammation and synthesising neurotransmitters (brain chemicals). Inadequate methylation capacity can lead to birth defects, depression, cognitive decline, and cancer.
There are multiple variations of the test to choose from, but some of the most important markers are:
Homocysteine – an amino acid associated with atherosclerosis that can become elevated when there is a need for folate, vitamin B6 and/or vitamin B12
S-Adenosyl Methionine (SAMe) – involved in many different reactions in the body
S-Adenosyl Homocysteine (SAH) – a key component of the methylation cycle, of which elevated levels are a risk factor for cancers and neurodegenerative diseases
5-methyl tetrahydrofolate (5MTHF) – the active form of vitamin B9, also known as folic acid or folate, which is best known for protecting against neural tube defects in pregnancy