Amanda has access to a wide range of genetic and pathology tests from private laboratories, which are valuable tools for assessing health and tailoring very personalised nutrition programmes. Please click on the links below, or scroll down for details of some of most commonly used tests, which include:
FitGenes Health & Wellbeing Genetic Profile Report
Genetic profiling offers unique insight into how your body responds to diet, exercise and lifestyle choices. A FitGenes Health & Wellbeing genetic profile report is based on the science of nutrigenomics, which considers the interaction between your genes, nutrition and lifestyle and how these influence gene behaviour. While we cannot change our genes, we can modify the way that they express themselves i.e. how they switch on and off and communicate with all cells of our body, to determine our health.
By linking our individual genetic signature with our family’s health history, our personal health history and current pathology testing (e.g. blood cholesterol, blood pressure, markers of inflammation, vitamin D), we can identify an individual’s predisposition towards certain health risks and make early interventions with regard to nutrition, lifestyle and exercise, before clinical symptoms start to appear.
The FitGenes genetic profile analyses a select range of genes that are key influencers of your general health, wellbeing and physical performance. They have been carefully selected on the basis of solid supporting scientific evidence, which demonstrates ways that we can modify their expression. As an accredited FitGenes practitioner, Amanda is able to interpret the results in conjunction with your personal health history and to offer practical advice on how to address any potential health issues, or to promote healthy ageing. A genetic profile is an invaluable tool in improving the gap between life expectancy and health expectancy i.e. rather than just living longer, aiming to extend your enjoyment of good health well into your later years of life.
The genes analysed are divided into the following categories:
Cell Defence – how your body protects cells and DNA from damage caused by oxidative stress
Inflammation – your body’s natural defence mechanism, which if uncontrolled, can be a key driver of almost all major diseases
Vitamin D receptors – present in all cells, these are a key influence on bone health, immunity, skin and the nervous system
Methylation and Homocysteine Metabolism – reflects the health of our cells and risk of chronic disease
Cardiovascular Health – the effectiveness of the system delivering oxygen and nutrients to every cell
Fat and Cholesterol Management – influences healthy weight management, appetite control and satiety
The test requires a simple DNA sample taken in clinic, from a mouth swab. You will receive a copy of your genetic profile with supporting information and Amanda will help you to interpret the results, to create a highly personalised health plan.
Do you have a 23andMe profile but don’t know what to make of the results? The data from your profile can be imported into the FitGenes software to provide an in-depth analysis of the genetic variations that influence the way your body responds to what you eat, how you exercise and the way you live. Amanda can then interpret the results to create a personalised health programme.
FitGenes has developed Carb Choice, a personalised genetic profile report based on your salivary amylase, AMY 1 gene, which determines how well you break down and tolerate starch from carbohydrates. This has a knock-on effect on many areas of health, so by understanding your Carb Choice gene profile, you can best manage health issues including weight management, diabetes, gluten intolerance and dental decay.
Using your Carb Choice genetic profile, Amanda can design a personalised intervention plan, including recommendations on the type and quantity of carbohydrates that you are best suited to consume.
The test requires a simple DNA sample taken from a mouth swab. You will receive a report containing your AMY 1 gene copy number variation and further supporting information, with dietary and lifestyle recommendations.
Pathology Testing (prices vary according to different markers requested)
Complete Microbiome Stool Test
This test provides the most comprehensive assessment available for digestive health and is the appropriate choice for patients presenting with sub-optimal gut function, but also anyone experiencing inflammatory symptoms, mood disorders or hormone imbalance. It uses forensic technology to measure:
- digestive, absorption and metabolic markers
- markers of inflammation, including a measurement of increased permeability of the gut lining or ‘leaky gut’
- immune reaction to gluten and a general marker for gut-immune function
- presence of hidden blood or mucous in the stool
- markers relating to liver detoxification of bacterial toxins
- levels of beneficial bacteria and the presence of 35 potentially harmful bacteria including Helicobacter pylori, which can cause stomach ulcers
- presence of yeast, including Candida, Geotrichum and Rhodotorula species
- parasitic or worm infection – checking for 14 different species
SIBO Test (Small Intestine Bacterial Overgrowth)
Excess bacteria in the upper part of the digestive tract produces gas via fermentation of dietary sugars and starches, that can then lead to symptoms such as bloating, flatulence, abdominal discomfort and nausea, as well as constipation or diarrhoea. SIBO is found to be present in 70% of IBS patients and the build-up of gas in the intestines can be triggered by easily fermentable foods e.g. high FODMAP foods, refined carbohydrates and sugars; by foods which are hard to digest, such as grains, dairy, meat or raw food; and also by insufficient chewing, stress, or over-eating.
The SIBO breath test checks for the production of hydrogen and methane gases, indicating if bacteria have overgrown in in the small intestine, where they are not usually found in large numbers. The results will help to tailor your nutrition programme, according to which type of gas is being produced and usually in conjunction with a stool test, which analyses the health of the colon, or large intestine (see Complete Microbiome Stool Test above).
DUTCH Plus Hormone Test (Dried Urine Test for Comprehensive Hormones)
An advanced hormone test, using cutting edge technology to provide an extensive profile of sex and adrenal hormones, along with their metabolites i.e. showing not only what your hormone levels are, but also how your body is breaking them down and excreting them, which is often of greater significance when investigating anxiety, depression, weight gain, hormonal symptoms such as erectile dysfunction, PMS, PMDD or menopausal hot flushes, low libido and insomnia.
Rather than looking at a single snapshot of hormones measured at one point in the day, the DUTCH Plus test analyses 24 hour urine samples and assesses the cortisol awakening response (CAR), using saliva samples. The CAR is a ‘mini stress test’ based on the pattern of cortisol production after waking and offers insight into health issues such as chronic pain, autoimmune conditions, depression, seasonal affective disorder, blood sugar dysregulation, weight gain, digestive issues, chronic fatigue and psychological burnout.
The comprehensive test includes:
- 2 progesterone metabolites
- androgens (testosterone and DHEAS) & 8 metabolites
- 3 forms of oestrogen & 10 metabolites
- total free cortisol, total metabolised cortisol and total cortisone across the day
- 3 cortisol metabolites
- 6 organic acids markers relating to liver detoxification, B vitamin deficiencies and neurotransmitter production (dopamine, adrenalin & noradrenalin)
- 8-OHdG, a marker for DNA damage
Organic Acids Test
The organic acids urine test is a valuable diagnostic tool for investigating underlying causes of a wide range of health issues, as it enables us to assess metabolic dysfunction. To use a car analogy, just as dashboard warning lights warn us about potential mechanical malfunction, the body has certain chemical indicators, known as organic acids, which can alert us to subtle biochemical imbalances that trigger the onset of symptoms of poor health. The test assesses:
- energy production within cells (including whether you are converting fats & carbs to energy in an efficient way)
- detoxification demands (liver health)
- neurotransmitter activity (brain chemical production)
- stress hormones
- vitamin deficiencies
- intestinal health
- oxidative stress and antioxidant need
Relevant for anyone who is chronically ill, tired, overweight, inflamed, stressed, anxious, has skin issues, neurological disorders, a compromised immune system, dysregulated blood sugar or other hormonal symptoms. Or simply anyone wishing to optimise their health – it is ideal as an annual health check.
The CardioION profile is a nutritional analysis which measures over 125 key nutrient biomarkers, enabling us to identify nutritional imbalances that may be a root cause of complex or chronic health conditions. The test evaluates:
- organic acids – chemical indicators of metabolic dysfunction, relating to energy production, liver detoxification, neurotransmitter production, B vitamin deficiencies, antioxidant requirements and digestive health
- fat soluble vitamins such as vitamins A, D and E, plus CoQ10
- minerals such as zinc, copper, selenium, magnesium, chromium and iodine
- toxic heavy metals such as lead, mercury, cadmium, nickel and arsenic
- markers of oxidative stress – which can lead to DNA damage within cells
- markers relating to cardiovascular health – including not only cholesterol and CRP, but other markers which contribute to inflammation and qualify the risk of cardiovascular disease, including lipoprotein (a), homocysteine, lipid peroxides and the blood clotting protein fibrinogen
- markers relating to hormone production, including insulin, testosterone and sex hormone binding globulin
- ratios of essential fats such as omega 3, 6 and 9 in relation to saturated and trans fats
- detailed information on amino acids, which are crucial building blocks for immune cells, muscle and brain chemicals
This test provides actionable insight and personalised treatment plans in relation to a wide range of health issues including depression, fatigue, weight gain, hormone imbalance, anxiety, mental health disorders, chronic pain, inflammatory skin conditions, allergies, osteoporosis, recurrent headaches or migraines, low libido, insomnia, hypertension, elevated cholesterol and diabetes. It is also the ideal comprehensive health check for people wanting to take a proactive approach to their health.
The kryptopyrroles test indicates the level of what is more simply called ‘mauve factor’ in your urine. It is the result of abnormal production of haemoglobin, of which the by-products are pyrroles, that then bind to vitamin B6 and zinc, causing large amounts of these nutrients to be excreted from the body. As a result, deficiencies occur, enzyme reactions cannot take place efficiently and pyrrole disorder is commonly linked to a wide range of symptoms, primarily mental health disorders (including anxiety, but also schizophrenia or bipolar disorder) and also elevated histamine.
Deficiency of vitamin B6 can lead to the development of depression, nausea, fatigue and mental confusion, while zinc deficiency can cause poor immune function, acne and skin rashes, poor appetite, low stomach acid and attention or motor disorders. Low zinc, B6 and magnesium deplete production of the neurotransmitters GABA and serotonin, which promote a sense of calm in the body, hence anxiety is one of the most common symptoms.
ALCAT Food Intolerance Test
There are many ways to test sensitivity to foods, but this blood test is a comprehensive and accurate way of measuring the reaction within your cells to over 450 substances, including foods, additives, environmental chemicals, inhalants and moulds. The results from the ALCAT test can help to determine which foods and other substances may trigger unwanted inflammation and associated gastrointestinal, metabolic or neurological disorders.
Comprehensive Thyroid Profile
Hypothyroidism (underactive thyroid) is one of the most undiagnosed or misdiagnosed health problems. TSH (thyroid stimulating hormone) is the medical gold standard for the diagnosis and treatment of thyroid dysfunction. Unfortunately, TSH alone does not provide a complete picture and controversy remains over what is used as a ‘normal’ TSH reference range. Hashimoto’s thyroiditis is an auto-immune disease where the body attacks and destroys its own thyroid gland. It is a leading cause of hypothyroidism, yet mainstream thyroid tests rarely check thyroid antibodies.
A comprehensive thyroid profile, based on a blood sample shows:
Unbound levels of T4 and T3 – these reflect the active components of thyroid hormone. This hormone assessment can identify not only overt hyper-and hypothyroidism, but subtle sub-clinical manifestations of thyroid dysfunction.
Reverse T3 – levels of which can increase when conversion of T4 to active T3 is impaired. Thyroid imbalances may arise from nutrient shortages, heavy metal exposure, adrenal stress, enzyme deficiencies, and other chronic illness.
Thyroid antibody levels – which help gauge autoimmune response and may reflect metabolic irregularities and hypothyroidism even when TSH and T4 levels appear normal. Thyroid antibody levels may rise in response to trauma, bacterial imbalance, inflammation, or progressive thyroid degeneration.
The methylation cycle is a biochemical pathway that manages or contributes to a wide range of biochemical functions including detoxification, supporting DNA (turning genes on and off), producing energy, reducing inflammation and synthesising neurotransmitters (brain chemicals). Inadequate methylation capacity can lead to birth defects, depression, cognitive decline, and cancer.
There are multiple variations of the test to choose from, but some of the most important markers are:
Homocysteine – an amino acid associated with atherosclerosis that can become elevated when there is a need for folate, vitamin B6 and/or vitamin B12
S-Adenosyl Methionine (SAMe) – involved in many different reactions in the body
S-Adenosyl Homocysteine (SAH) – a key component of the methylation cycle, of which elevated levels are a risk factor for cancers and neurodegenerative diseases
5-methyl tetrahydrofolate (5MTHF) – the active form of vitamin B9, also known as folic acid or folate, which is best known for protecting against neural tube defects in pregnancy